I-Canine Cys-C: Ukubhekisisa Le Maka Renal

Eminyakeni embalwa edlule, i-cystatin C ibilokhu ithola ukunakwa okwengeziwe emithini yezilwane-hhayi njengokuhlola okuyisimangaliso, kodwa njengento engase ivale igebe elishiywe omaka bendabuko njenge-creatinine. Umbono uqondile: I-Cys-C iphrotheni encane ekhishwa kancane kancane ngamaseli angama-nucleated yonke indawo emzimbeni. Ishelela kusihlungi se-glomerular kalula, bese iphinda imuncwe futhi iphuke kuma-proximal tubules. Lapho ukuhlunga kuncipha, kanjalo nokukhululeka kwayo, futhi amazinga egazi ayakhuphuka. Ngakho-ke, ngokombono, ilandelela ukusebenza kwe-glomerular kahle.

Kodwa lapha kulapho kuba nentshisekelo khona. I-Creatinine, kukho konke ukusetshenziswa kwayo okusabalele,{1}inendawo eyimpumputhe{2}eyaziwa kakhulu{2}}egoba ubunzima bemisipha, ubudala, kanye nesimo somzimba. Inja endala enezinso ezingaqinile ingase ibonise inani le-creatinine elibukeka limsulwa ngokuphelele. UCys-C, ngakolunye uhlangothi, akabonakali enendaba kakhulu nemisipha. Lokho kwenza kube umbono wesibili ongase ube wusizo lapho izinombolo ezijwayelekile zingacacile.

Udokotela wezilwane angafinyelela nini ngempela kulokhu kuhlolwa? Kufika izimo ezimbalwa engqondweni. Uma kusolakala ukuthi isifo sezinso kodwa i-creatinine ne-BUN zisazulazula ebangeni elivamile, i-Cys{1}C ingase inikeze ukugudluzwa ohlangothini olulodwa noma kwenye. Ezinjeni esezitholwe zinesifo sezinso esingamahlalakhona, ukusebenzisa i-Cys-C serially kungasiza ukudweba isithombe esicacile sokuthi izinto ziqhubeka kanjani{4}noma cha. Izinja ezindala, kanye nalezo ezinomlando wezinkinga ze-urinary tract, zingase zibe abantu abanengqondo bokuhlolwa ngezikhathi ezithile, kuye ngephrofayili yabo yobungozi. Sesikushilo lokho, akekho umuntu onengqondo elungile ongathembela ku-Cys-C kuphela. Idinga ukufundwa eduze kwe-creatinine, i-BUN, amandla adonsela phansi aqondene nomchamo, i-UPC, okutholwe ukuhlolwa ngokomzimba, kanye nendaba yenja uqobo. Kungaleso sikhathi kuphela lapho uthola okuthile okufana nesithombe esiphelele.

Into eyodwa okufanele igcizelele: ayikho inombolo eyodwa etshela yonke indaba. Umphumela we-Cys ophakeme{1}}Udinga ukutolikwa ngokomongo{2}}izimpawu zomtholampilo, amanye amalebhu, kanye nokuxilongwa okwengeziwe ukuze kutholwe ukuthi kwenzakalani ngempela nokuthi sekuhambe ibanga elingakanani.

Njengoba udokotela wezilwane utshekela kakhulu ekubambeni izinto kusenesikhathi nokuphatha ngokuqhubekayo, ama-biomarker afana ne-Cys-C athola indawo yawo ekuhlolweni kwezinso okujwayelekile. Inani langempela, nokho, alikho kunoma yimuphi umphumela wokuhlola owodwa kodwa ekusebenziseni lawa mathuluzi ngokucabangisisa, ukubuka amathrendi ngokuhamba kwesikhathi, kanye nokuvumela idatha yazise{2}}ingasho{3}}izinqumo zomtholampilo.